Influence of xenon perfusion on adrenalin dependent atrial contractility
АннотацияBackground: Many anesthetic agents show a cardiodepressant effect. In cardiac surgery this may limit their application. We tested the hypothesis that xenon does not affect the positive inotropic effect of adrenalin in human right atrial muscle bundles. Methods: 18 right atrial appendages from 17 patients were harvested. Thin myocardial muscle strips were prepared under stereomicroscopic control, connected to isometric force transducers and placed in an organ bath. Force of contraction was analysed from 10 pmol to 1 mmol adrenalin. Differences in force development were compared after perfusion of the Krebs-Henseleit solution with 100 % xenon for 30 minutes at 60 bpm and 37 °C in the open contraction chamber. Results: Xenon perfusion did not alter myocardial force of contraction. The positive inotropic impact of adrenalin did not differ between the muscles exposed to xenon and the control group. Conclusion: The present findings indicate that the inotropic effect of adrenalin is not affected by xenon perfusion of human right atrial muscle strips.
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