Influence of xenon perfusion on adrenalin dependent atrial contractility
AbstractBackground: Many anesthetic agents show a cardiodepressant effect. In cardiac surgery this may limit their application. We tested the hypothesis that xenon does not affect the positive inotropic effect of adrenalin in human right atrial muscle bundles. Methods: 18 right atrial appendages from 17 patients were harvested. Thin myocardial muscle strips were prepared under stereomicroscopic control, connected to isometric force transducers and placed in an organ bath. Force of contraction was analysed from 10 pmol to 1 mmol adrenalin. Differences in force development were compared after perfusion of the Krebs-Henseleit solution with 100 % xenon for 30 minutes at 60 bpm and 37 °C in the open contraction chamber. Results: Xenon perfusion did not alter myocardial force of contraction. The positive inotropic impact of adrenalin did not differ between the muscles exposed to xenon and the control group. Conclusion: The present findings indicate that the inotropic effect of adrenalin is not affected by xenon perfusion of human right atrial muscle strips.
Goto T, Hanne P, Ishiguro Y, Ichinose F, Niimi Y, Mori- ta S. Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia. Anaesthesia. 2004;59:1178-83.
Bedi A, Murray JM, Dingley J, et al. Use of xenon as a sedative for patients receiving critical care. Exploration of xenon as a potential cardiostable sedative: a comparison with propofol after cardiac surgery. Critical Care Medicine 2003;31: 2470-7.
Hanouz Jl, Massetti M, Guesne G, Chanel S, Babatsi G, Rouet R, Ducouret P, Khayat A, Galateau F, Bricard H, Gerard JL: In vitro effects of desflurane, servoflurane, isoflurane, and halothane in isolated human right atria. Anesthesiology 2000; 92:116-24.
Lynch C III: Differential depression of myocardial contractility by halothane and isoflurane in vitro. Anesthesiology 1986; 64:620-31
Liakopoulos OJ, Muhlfeld C, Koschinsky M, Coulibaly MO, Schondube FA, DorgeH. Progressive loss of myocardial contractile function despite unimpaired coronary blood flow after cardiac surgery. Basic Res Cardiol. 2005;100:75-83.
Gillies M, Bellomo R, Doolan L, Buxton B. Bench-to- bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review. Crit Care. 2005;9:266-79.
Preckel B, Schlack W. Inert gases as the future inhalatio- nal anaesthetics? Best practise and research clinical anaesthesiology. 2005:19(3):365-79
Sanders RD, Franks NP, Maze M. Xenon: no stranger to anaesthesia. British Journal of Anesthesia 2003;91:709- 17
Hettrick DA, Pagel PS, Kersten JR, Tessmer JP, Bosnjak ZJ, Georgieff M, Warltier DC. Cardiovascular effects of xenon in isoflurane-anesthetized dogs with dilated cardiomyopathy. Anesthesiology. 1998;89:1166-73
Schroth SC, Schotten U, Alkanoglu O, Reyle-Hahn MS, Hanrath P, Rossaint R. Xenon does not impair the responsiveness of cardiac muscle bundles to positive inotropic and chronotropic stimulation. Anesthesiology. 2002 Feb;96(2):422-7.
Nakayama H, Takahashi H, Okubo N, Miyabe M, Toyoo- ka H. Xenon and nitrous oxide do not depress cardiac function in an isolated rat heart model. Can J Anaesth. 2002 Apr;49(4):375-9.