Antibodies to human heat shock protein 60 and mycobacterial heat shock protein 65 in patients with coronary atherosclerosis
AbstractObjective: In patients with coronary atherosclerosis, conflicting results related to the influence of heat shock protein antibodies exist. Our aim was to determine antibodies against human HSP60 and mycobacterial HSP65 in sera of patients with coronary atherosclerosis. Methods: Immunoblot analyses of antibodies against human HSP60 and mycobacterial HSP65 were performed in serum from 117 patients with coronary atherosclerosis and 50 patients without angiographic evidence of coronary atherosclerosis. Results: Anti human HSP60 autoantibodies were found in 8 patients undergoing CABG (p=0,11). Anti mycobacterial HSP65 antibodies were found in six CABG patients and one patient without coronary atherosclerosis (p=0,68). Conclusions: This result is consistent with a previous report, suggesting that antibodies against human HSP60 or mycobacterial HSP65 may not be involved in coronary atherosclerosis.
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