Antibodies to human heat shock protein 60 and mycobacterial heat shock protein 65 in patients with coronary atherosclerosis

  • A. E. Schafler Department of Cardiac Surgery, University of Ulm, Germany
  • Ph. Weigold Department of Cardiac Surgery, University of Ulm, Germany


Objective: In patients with coronary atherosclerosis, conflicting results related to the influence of heat shock protein antibodies exist. Our aim was to determine antibodies against human HSP60 and mycobacterial HSP65 in sera of patients with coronary atherosclerosis. Methods: Immunoblot analyses of antibodies against human HSP60 and mycobacterial HSP65 were performed in serum from 117 patients with coronary atherosclerosis and 50 patients without angiographic evidence of coronary atherosclerosis. Results: Anti human HSP60 autoantibodies were found in 8 patients undergoing CABG (p=0,11). Anti mycobacterial HSP65 antibodies were found in six CABG patients and one patient without coronary atherosclerosis (p=0,68). Conclusions: This result is consistent with a previous report, suggesting that antibodies against human HSP60 or mycobacterial HSP65 may not be involved in coronary atherosclerosis.


Hoppichler F, Lechleitner M, Traweger C, Schett G, Dzien A, Sturm W, Xu Q. Changes of serum antibodies to heat-shock protein 65 in coronary heart disease and acute myocardial infarction. Atherosclerosis. 1996;126:333-8.

Birnie DH, Holme ER, McKay IC, Hood S, McColl KE, Hillis WS. Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mecha-nism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk. Eur Heart J. 1998;19:387-94.

Mukherjee M, De Benedictis C, Jewitt D, Kakkar VV. Association of antibodies to heat-shock protein-65 with percutaneous transluminal coronary angioplasty and sub-sequent restenosis. Thromb Haemost. 1996;75:258-60.

Hoppichler F, Koch T, Dzien A, Gschwandtner G, Lechleitner M. Prognostic value of antibody titre to heat- shock protein 65 on cardiovascular events. Cardiology. 2000;94:220-3.

Zhu J, Quyyumi AA, Rott D, Csako G, Wu H, Halcox J, Epstein SE. Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis. Circulation. 2001;103:1071-5.

Veres A, Szamosi T, Ablonczy M, Szamosi T Jr, Singh M, Karadi I, Romics L, Fust G, Prohaszka Z. Comple¬ment activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease. Eur J Clin Invest. 2002;32:405- 10.

Schett G, Xu Q, Amberger A, Van der Zee R, Recheis H, Willeit J, Wick G. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest. 1995;96:2569-77.

Mahdi OS, Horne BD, Mullen K, Muhlestein JB, Byrne GI. Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease. Circulation. 2002;106:1659-63.

Ciervo A, Visca P, Petrucca A, Biasucci LM, Maseri A, Cassone A. Antibodies to 60-kilodalton heat shock pro¬tein and outer membrane protein 2 of Chlamydia pneu¬moniae in patients with coronary heart disease. Clin Di- agn Lab Immunol. 2002;9:66-74.

Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation. 1998;98:300-7.

Xu Q, Kiechl S, Mayr M, Metzler B, Egger G, Oberhol- lenzer F, Willeit J, Wick G. Association of serum anti¬bodies to heat-shock protein 65 with carotid atherosclerosis : clinical significance determined in a follow-up study. Circulation. 1999;14:1169-74.

Как цитировать
Schafler, A., & Weigold, P. (2018). Antibodies to human heat shock protein 60 and mycobacterial heat shock protein 65 in patients with coronary atherosclerosis. Бюллетень международной научной хирургической ассоциации, 1(1), 27-29. извлечено от
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