Serum antibodies to human heat shock protein 70 in patients with coronary atherosclerosis
АннотацияAbstract: Previous studies suggest that antibodies to human heat shock protein 70 have a higher frequency in patients with risk factors for coronary atherosclerosis. We examined whether circulating anti-human heat shock protein 70 antibodies are associated with coronary artery disease. In a case control study preoperative blood samples for immunoblot analyses from 117 patients with severe coronary artery disease and 50 patients without coronary atherosclerosis were tested. Serum heat shock protein 70 antibodies were detectable in 8 patients undergoing bypass operations and one patient with aortic valve replacement. No association between anti-heat shock protein 70 IgG seropositivity and the prevalence of coronary artery disease was found (p = 0.28). These data provide evidence that anti human heat shock protein 70 IgG antibodies are not associated with coronary atherosclerosis.
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