Резистентность к аспирину: обзор современных представлений о возможных механизмах
Аннотация
Антиагрегантная терапия является одной из основ лечения атеротромботических осложнений сердечно¬сосудистых заболеваний, а аспирин - самым назначаемым препаратом из этой группы. Несмотря на его до¬казанную эффективность, многие пациенты, принимающие аспирин, испытывать сердечно-сосудистые ка¬тастрофы. Механизм резистентности до сих пор точно не изучен, однако известно, что в него могут быть вовлечены различные факторы, начиная от плохой приверженности к лечению, и заканчивая генетическим полиморфизмом гликопротеиновых рецепторов тромбоцитов. Очевидно, что необходимы дальнейшие иссле¬дования на эту тему, так как знание точного механизма резистентности поможет оптимизировать тера¬пию и предотвратить большое количество атеротромботических осложнений.Литература
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