Mechanisms of neurologic disorders in syndrome of Down

Ю. А. Колчева


In recent decades, there has been a significant increase in the incidence of Down syndrome. The severity of neurological disorders in these children is not the same. Despite the wide occurrence of this genetic anomaly, the insufficient number of works is devoted to the analysis of changes in neurological status in such children, pathogenetic mechanisms leading to cognitive deficiency are not fully understood. In this paper, we present the results of the assessment of changes in the neurological status of patients with Down's syndrome, morphometric features of the structure of the brain, the rationale for possible pathogenetic mechanisms of progression and the occurrence of cerebral disorders in such children.


Down's syndrome, trisomy of 21 chromosomes, neurological status, MRI of the brain, morphometry


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