Autologous bone marrow stem cells transplantation in management of patients with spinal cord injury

  • Е. Р. Черных Institute of Clinical Immunology RAMS SB
  • В. В. Ступак Institute of traumatology and orthopedia
  • Ж. М. Мурадов Institute of traumatology and orthopedia
  • М. Ю. Сизиков Institute of traumatology and orthopedia
  • Е. Я. Шевела Institute of Clinical Immunology RAMS SB
  • О. Ю. Леплина ФГУ «НИИ травматологии и ортопедии»
  • А. А. Останин Institute of Clinical Immunology RAMS SB
Keywords: spinal cord injury, stem cells, transplantation

Abstract

Bone marrow-derived stem cells can differentiate into neural cells and animal models of stroke, spinal cord and brain trauma have improved with transplantation of stem cells. In this study we investigated whether the autologous transplantation of bone marrow cells (auto-BMT) in complex therapy of spinal cord injury patients is safety and improve functional recovery in the late period after spinal trauma. Thirty six patients (26 male and 10 female, 18-53 years old) were enrolled in this study. Patients of control group (n=18) underwent surgical operation of meningomye- loradiculolis, and surgery treatment of patients in basic group (n=18) was supplemented with auto-BMT. Transplantation of BM stem cells, putted into the cyst cavity and transfused intravenously, was well tolerated and did not cause allergic or inflammatory reactions in early and long-term period after surgery as well as ossification in the nervous tissue. The ASIA, Bartel, and Ashworth scale assessment revealed significant increase of neurological improvement frequency in basic group in compare to control one (66,7 vs 27,8%, р=0,02 Fisher exact). Decrease of neurological deficit included both sensory and motor activity improvement and enhancement of conducting sensory function. Thus, auto-BMT may constitute a novel safety strategy for the treatment of patients in the late period after spinal trauma.

References

Косичкин М. М. Социально-гигиеническая характеристика инвалидности вследствие травматического поражения спинного мозга и потребность инвалидов в медикосоциальной помощи: Обзор. информ. - М., 1996.
Bracken MB. Holford TR. Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III // J. Neurosurg Spine.- 2002.- Vol.3.- P.259-266.
Chen J., Li Y., Zhang Z., Wang L., et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats // Stroke.- 2001.- Vol. 32.- P.1005- 1011.
Chopp M., Zhang X.H., Li Y., et al. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation // Neuroreport.- 2000.- Vol. 11.- P.3001-3005.
Corti S., Locatelli1 F., Strazzer S., et al. Neuronal generation from somatic stem cells: current knowledge and perspectives on the treatment of acquired and degenerative central nervous system disorders // Current Gene Therapy.- 2003.- Vol. 3.- P. 247-272.
Hofstetter C.P., Schwarz E.J., Hess D., et al., Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery // Proc. Natl. Acad. Sci. U.S.A..- 2002.- Vol. 99.- P.2199- 2204.
Korbling M., Estrov Z. Adult stem cells for tissue repair — a new therapeutic concept? // N. Engl. J. Med.- 2003.- Vol. 349.- P.570-582.
Schultz S. S. Adult stem cell application in spinal cord injury // Current Drug Targets.- 2005.- Vol. 6.- P.63-73.
Svendsen C.N., Caldwell M.A., Ostenfeld T. Human neural stem cells: isolation, expansion and transplantation.// Brain Pathol.-1999.- Vol. 9.- P.499-513.
Published
2018-05-31
How to Cite
Черных, Е., Ступак, В., Мурадов, Ж., Сизиков, М., Шевела, Е., Леплина, О., & Останин, А. (2018). Autologous bone marrow stem cells transplantation in management of patients with spinal cord injury. Bulletin of the International Scientific Surgical Association, 1(3), 11-13. Retrieved from http://surgjournal.ru/index.php/BISSA/article/view/102
Section
Original Articles